In the news
Rabies is rare but be aware.
Rabies may be the most feared disease on the planet, and with justification. Although rare in the United States, where there are fewer than five cases per year, ten thousand times that many persons die from the disease in the rest of the world. It is almost universally fatal and to date fewer than 30 persons have survived; none have been neurologically intact.
The CDC has justifiably raised an alarm regarding rabies. So far in 2026 more than 1700 persons have required treatment for exposure to an animal with confirmed or suspected rabies. Most exposures have occurred east of the Mississippi but the virus has been recovered from animals throughout the United States. Bats are the most common animal to be infected but recent cases have included raccoons, skunks, coyotes, beavers, petting zoo goats and groundhogs. Outbreaks occur regularly among ground squirrels in California.
Post-exposure treatment is one of the greatest success stories in medicine. It is nearly 100 percent effective. Failures are so rare as to be reportable in the medical literature.
It is not necessary to have a recognized animal bite to become infected. A bat bite, for instance, may be so painless as to be unapparent. Thus any close contact with a bat, especially during daytime –healthy bats are not active during the day – should be treated as an exposure. Infected saliva may be a source of infection, even if there is no obvious break in the skin.
Nocturnal animals such as raccoons, skunks and coyotes are presumed to be infected if they are near humans in daytime.
Of the approximately 60,000 cases of rabies that occur worldwide each year, Africa and Asia account for about 95 percent, mostly transmitted by dogs. Accordingly, anyone traveling to those continents should be aware of the risk. Bats are cave-dwellers and cave explorers should consider getting the rabies vaccine prior to travel to areas known to have infected bats.
Considering the high risk of exposure and the vanishingly small risk of post-exposure treatment, a prudent approach strongly recommends the latter.
Lifestyle
Lose weight but not your brain
The new class of weight loss drugs, known as GLP-1 receptor agonists, arrived on the scene a relatively short time ago, and as we might have expected, now that millions of Americans are taking them some serious side effects have emerged. These drugs reduce the appetite to a significant degree. The good news is that they work; the bad news is that by reducing food intake they limit the availability of some critical nutrients.
Wernicke encephalopathy is a severe brain disorder whose symptoms include malfunction of the eye muscles, resulting in abnormal eye movements, unsteady gait and mental deterioration. It has been recognized for over a century among alcoholics and victims of beri-beri. The primary cause is the severe lack of thiamine, vitamin B1. It has been reported among persons who have undergone bariatric surgery, a procedure in which the stomach is reduced to the size of a hen’s egg. Now it has appeared in persons taking GLP-1 drugs, especially if they have vomiting, a not uncommon side effect.
In all three conditions, alcoholism, post-bariatric surgery and GLP-1 intake, failure to take in nutritious food includes failure to take in adequate vitamins and minerals. (Note: osteoporosis has been observed in bariatric surgery patients. Expect to see the same disorder in drug-takers in the next couple of years.)
Without early recognition and treatment, Wernicke encephalopathy is not always reversible and can lead to death. Everyone taking this class of drugs should be made aware of this hazard.
We have yet to see the toll that the new medication will exact.